Precision medicine
The availability of different patient-specific omics data as well as measurements from a single cell enable research of solutions at the level of an individual instead of an "average patient".
We are developing and optimising kinetic models of metabolism, pharmacokinetics and signalling. Other types of processes can be addressed depending on the amount of available information.
Our particular strength is the experience in the use of global stochastic optimisation methods in parameter estimation and optimisation tasks. In both cases, we are implementing different types of constraints to improve the credibility of results.
Our main modelling tool is software COPASI. We have used COPASI alone and in combination with COPASI wrapper SpaceScanner to manage parallel optimisation runs of global stochastic optimisation methods.
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