Modeling of central metabolism

(leader researcher Agris Pentjuss)

Metabolic engineering is a research direction where we collaborate with the Institute of Microbiology and Biotechnology of University of Latvia (prof. Uldis Kalnenieks) and prof. Daviad A. Fell (Oxford Brookes University, UK). So far we have mostly concentrated on the modeling of Zymomonas mobilis (both stoichiometric and dynamic models) but the scope will be extended.

Important experience was collected by Agris Pentjuss during his stay at David Fell group in Oxford-Brookes in 2013.

Synthetic Biology

(leader senior researcher E.Stalidzans)

Synthetic Biology (SynBio) aims to modify existing organisms or create new ones using engineering approach. Registry of Standard Biological Parts is one of consequences of engineering approach used deveolping technical systems. Now stadartized parts can be used in biology.

SynBio holds a number of promises to secure or improve quality of life. On the other hand there are potential and perceived risks due to deliberate or accidental damage. In addition, ethical issues related to the nature of living beings are arising. In order to ensure the successful development of this new scientific field it is necessary to gather information about its risks and to devise adequate bio-safety strategies to minimize them.

Egils Stalidzans is a member of International Association Synthetic Biology.

Computational methods of Systems Biology

(leader - senior researcher E.Stalidzans)

Systems Biology (SysBio) comes as next level of our modelling activities indicated in other topics of research interest. We see there enormous potential for development where our skills can be applied in global research topics. Application of control theory looking at complexity of living systems, development of SysBio dedicated software, development of different IT support are directions where we have high potential.

Currently we study the BioModels database using the new version of COPASI. Currently we investigate recognition of control networks in molecular processes focusing on control loops, their interaction to get closer to the miracle of stability of a cell.

Another topic of research is the process of glycolisis because of rich amount of data. We are currently looking for possibilities to extract more knowledge of existing data.

Dynamic modelling and control of multiobject biological systems

(leader - senior researcher A. Zacepins)

Under name multiobject biological systems is meant wide range of possible systems that consist of high number individual units. Examples are: forest as a system with trees as multiobjects, fish crowd as a system and fish as a multiobject.

As a model organism a bee colony is used to apply and test different approaches for dynamic modelling under data insufficiency. A methodology has been created 1) to develop the dynamic model of biological system and 2) to develop a control system for control of the biological system represented as a set of control loops.

Bee wintering

(leader - senior researcher A. Zacepins)

Bee wintering is related to dynamic modelling of biological systems. To assess efficiency of bee wintering building in a given environment a model in software POWERSIM is developed to indicating effect of temperature control in the building to reduce metabolic heating when bees use honey. 

Currently two bee wintering buildings are in operation at Strazdu street 1. Wintering at this stage is part of Precision Apiculture project